The frequency of transplantation between MHC-matched unrelated donors and recipients increases in clinic each year. Minor histocompatibility antigens (minor H Ags) are substantial impediments to MHC-matched solid tissue and bone marrow transplantation. From an antigenic standpoint, transplantation between MHC-matched individuals has the potential to be remarkably complex.

However, the extent of the immune response is simplified by the phenomenon of immunodominance. H60 congenic mouse strains, we are investigation the nature of CD8 T cell response to a single dominant minor H Ag, H60, which overwhelms the CD8 T cell responses to other minor H Ags, H28, H4, H13, H7, and HY. The Understanding the immune kinetics and properties of T cells involved in H60 specific response has important implications in tissue transplantation and vaccine design.